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Hiroyu Hatano discusses the mechanisms of suboptimal immune recovery in patients receiving antiretroviral treatment and offers suggestions for means of better understanding this increasingly important area of HIV research. Given the increasing availability of antiretroviral drugs that can durably and safely suppress HIV replication, one of the major challenges in the next decade of HIV care will be to restore normal immunologic health. Suboptimal CD4 T-cell responses to antiretroviral therapy ART have been associated with substantial increases in the risk of AIDS-related and non-AIDS-related mortality and morbidity, including cardiovascular disease, liver disease, renal disease, and malignancies. Several clinical factors have been associated with immunologic nonresponse, including older age, male gender, lower nadir CD4 count, and hepatitis C virus coinfection.
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